The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease
MD Crowther, AK Sewell - Current Opinion in Immunology, 2021 - Elsevier
Current Opinion in Immunology, 2021•Elsevier
Highlights•MR1 is an evolutionarily conserved antigen presentation platform.•MR1 presents
endogenous and bacterial metabolite ligands to T-cells.•Recent data shows MR1-restricted
T-cells may play important roles in cancer.•The conserved nature of MR1 may allow pan-
population therapies for many diseases.MR1 is a ubiquitously expressed, monomorphic
antigen presenting molecule that has been largely preserved throughout mammalian
evolution. The primary role of MR1 is to present conserved microbial metabolites to highly …
endogenous and bacterial metabolite ligands to T-cells.•Recent data shows MR1-restricted
T-cells may play important roles in cancer.•The conserved nature of MR1 may allow pan-
population therapies for many diseases.MR1 is a ubiquitously expressed, monomorphic
antigen presenting molecule that has been largely preserved throughout mammalian
evolution. The primary role of MR1 is to present conserved microbial metabolites to highly …
Highlights
- MR1 is an evolutionarily conserved antigen presentation platform.
- MR1 presents endogenous and bacterial metabolite ligands to T-cells.
- Recent data shows MR1-restricted T-cells may play important roles in cancer.
- The conserved nature of MR1 may allow pan-population therapies for many diseases.
MR1 is a ubiquitously expressed, monomorphic antigen presenting molecule that has been largely preserved throughout mammalian evolution. The primary role of MR1 is to present conserved microbial metabolites to highly abundant mucosal-associated invariant T (MAIT) cells. The role of MAIT cells and other MR1-restricted T cells (MR1T) has been recently extended to immunomodulation during cancer. MR1Ts have also been implicated in autoimmune disease. The highly conserved nature of MR1 across the human population is in stark contrast to the MHC molecules recognised by conventional αβ T-cells, therefore MR1Ts may form fertile ground for the development of pan-population T-cell immunotherapeutics for a wide range of important morbidities.
Elsevier
