[HTML][HTML] A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice
R Ito, I Katano, K Kawai, M Yagoto, T Takahashi… - American Journal of …, 2017 - Elsevier
Graft-versus-host disease (GVHD) is a major complication of allogenic bone marrow
transplantation and involves the infiltration of donor CD4+ and/or CD8+ T cells into various
organs of the recipient. The pathological role of human CD4+ and CD8+ T cells in GVHD
remains controversial. In this study, we established two novel xenogeneic (xeno)-GVHD
models. Human CD4+ or CD8+ T cells were purified from peripheral blood and were
transplanted into immunodeficient NOD/Shi-scid IL2rg null (NOG) mice. Human CD8+ T …
transplantation and involves the infiltration of donor CD4+ and/or CD8+ T cells into various
organs of the recipient. The pathological role of human CD4+ and CD8+ T cells in GVHD
remains controversial. In this study, we established two novel xenogeneic (xeno)-GVHD
models. Human CD4+ or CD8+ T cells were purified from peripheral blood and were
transplanted into immunodeficient NOD/Shi-scid IL2rg null (NOG) mice. Human CD8+ T …
