[HTML][HTML] SIRPα/CD47 axis controls the maintenance of transplant tolerance sustained by myeloid-derived suppressor cells
S Pengam, J Durand, C Usal, V Gauttier, N Dilek… - American Journal of …, 2019 - Elsevier
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature
hematopoietic precursors known to suppress immune responses. Interaction of SIRP alpha
(SIRPα), expressed by myeloid cells, with the ubiquitous receptor CD47 is an important
immune checkpoint of the innate response regulating macrophages and dendritic cells
functions. We previously described that MDSC expressing SIRPα accumulated after
transplantation and maintained kidney allograft tolerance. However, the role of the …
hematopoietic precursors known to suppress immune responses. Interaction of SIRP alpha
(SIRPα), expressed by myeloid cells, with the ubiquitous receptor CD47 is an important
immune checkpoint of the innate response regulating macrophages and dendritic cells
functions. We previously described that MDSC expressing SIRPα accumulated after
transplantation and maintained kidney allograft tolerance. However, the role of the …
