A20: A multifunctional tool for regulating immunity and preventing disease
BA Malynn, A Ma - Cellular immunology, 2019 - Elsevier
A20, also known as TNFAIP3, is a potent regulator of ubiquitin (Ub) dependent signals. A20
prevents multiple human diseases, indicating that the critical functions of this protein are
clinically as well as biologically impactful. As revealed by mouse models, cell specific
functions of A20 are linked to its ability to regulate diverse signaling pathways. Aberrant
expression or functions of A20 in specific cell types underlie divergent disease outcomes.
Discernment of A20's biochemical functions and their phenotypic outcomes will contribute to …
prevents multiple human diseases, indicating that the critical functions of this protein are
clinically as well as biologically impactful. As revealed by mouse models, cell specific
functions of A20 are linked to its ability to regulate diverse signaling pathways. Aberrant
expression or functions of A20 in specific cell types underlie divergent disease outcomes.
Discernment of A20's biochemical functions and their phenotypic outcomes will contribute to …
