[HTML][HTML] Ischemia reperfusion injury facilitates lung allograft acceptance through IL-33-mediated activation of donor-derived IL-5 producing group 2 innate lymphoid …
Pathways regulating lung alloimmune responses differ from most other solid organs and
remain poorly explored. Based on our recent work identifying the unique role of eosinophils
in downregulating lung alloimmunity, we sought to define pathways contributing to
eosinophil migration and homeostasis. Using a murine lung transplant model, we have
uncovered that immunosuppression increases eosinophil infiltration into the allograft in an IL-
5-dependent manner. IL-5 production depends on immunosuppression-mediated …
remain poorly explored. Based on our recent work identifying the unique role of eosinophils
in downregulating lung alloimmunity, we sought to define pathways contributing to
eosinophil migration and homeostasis. Using a murine lung transplant model, we have
uncovered that immunosuppression increases eosinophil infiltration into the allograft in an IL-
5-dependent manner. IL-5 production depends on immunosuppression-mediated …
