[PDF][PDF] Role of interleukin-18 in the development and pathogenesis of AIDS
A Iannello, S Samarani, O Debbeche, C Tremblay… - AIDS Rev, 2009 - researchgate.net
Interleukin-18 is a proinflammatory, proapoptotic, and proatherogenic cytokine belonging to
the interleukin-1 family of cytokines. The cytokine exerts many unique immunologic and
biological effects. It is produced as a biologically inactive and leaderless precursor protein,
which must be cleaved into its mature form by caspase-1. The caspase-1 also exists in an
inactive precursor in the cytosol and needs proteolytic auto-cleavage, which is catalyzed by
the assembly of a multi-protein complex called inflammasome. Inside the circulation …
the interleukin-1 family of cytokines. The cytokine exerts many unique immunologic and
biological effects. It is produced as a biologically inactive and leaderless precursor protein,
which must be cleaved into its mature form by caspase-1. The caspase-1 also exists in an
inactive precursor in the cytosol and needs proteolytic auto-cleavage, which is catalyzed by
the assembly of a multi-protein complex called inflammasome. Inside the circulation …
