Stimulation of histone deacetylase activity by metabolites of intermediary metabolism
M Vogelauer, AS Krall, MA McBrian, JY Li… - Journal of Biological …, 2012 - ASBMB
Histone deacetylases (HDACs) function in a wide range of molecular processes, including
gene expression, and are of significant interest as therapeutic targets. Although their native
complexes, subcellular localization, and recruitment mechanisms to chromatin have been
extensively studied, much less is known about whether the enzymatic activity of non-sirtuin
HDACs can be regulated by natural metabolites. Here, we show that several coenzyme A
(CoA) derivatives, such as acetyl-CoA, butyryl-CoA, HMG-CoA, and malonyl-CoA, as well as …
gene expression, and are of significant interest as therapeutic targets. Although their native
complexes, subcellular localization, and recruitment mechanisms to chromatin have been
extensively studied, much less is known about whether the enzymatic activity of non-sirtuin
HDACs can be regulated by natural metabolites. Here, we show that several coenzyme A
(CoA) derivatives, such as acetyl-CoA, butyryl-CoA, HMG-CoA, and malonyl-CoA, as well as …
