Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes
Z Zhang, C Filzmayer, Y Ni, H Sültmann, P Mutz… - Journal of …, 2018 - Elsevier
Background & Aims Hepatitis B virus (HBV) and D virus (HDV) co-infections cause the most
severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown
how the host cell senses HDV and if this defense affects HDV replication. We aim to
characterize interferon (IFN) activation by HDV, identify the responsible sensor and evaluate
the effect of IFN on HDV replication. Methods HDV and HBV susceptible hepatoma cell lines
and primary human hepatocytes (PHH) were used for infection studies. Viral markers and …
severe form of viral hepatitis. HDV induces an innate immune response, but it is unknown
how the host cell senses HDV and if this defense affects HDV replication. We aim to
characterize interferon (IFN) activation by HDV, identify the responsible sensor and evaluate
the effect of IFN on HDV replication. Methods HDV and HBV susceptible hepatoma cell lines
and primary human hepatocytes (PHH) were used for infection studies. Viral markers and …
